• Cryosurgical devices and techniques
• Computerized planning of cryosurgery
• Mathematical modeling of phase change problems
• Solid mechanics aspects of low temperature biology
• Experimental solid mechanics in cryobiology
• Uncertainty in measurements and mathematical modeling
• Temperature controlled microscopy and macroscopy
• Temperature measurements
• Energy storage systems
• Hyperthermia and Thermal Ablation

Cryosurgical Devices and Techniques

Rabin, Y. (1994): Destruction of biological tissues by controlled freezing, D.Sc. Thesis, Department of Mechanical Engineering, Technion - Israel Institute of Technology, Haifa, Israel. Thesis (PDF 23.2MB)

Rabin, Y., Shitzer, A. (1996): A new cryosurgical device for controlled freezing, Part I: Setup and validation test. Cryobiology, 33:82-92. Article (PDF 0.2MB)

Rabin, Y., Coleman, R., Mordohovich, D., Ber, R.,  Shitzer, A. (1996): A new cryosurgical device for controlled freezing, Part II: In vivo experiments on rabbits’ hind thighs. Cryobiology, 33:93-105. Article (PDF 2.1MB)

Rabin, Y., Julian, T.B., Wolmark, N. (1997): A compact cryosurgical apparatus for minimal-invasive cryosurgery. Biomedical Instrumentation & Technology, 31:251-258. Article (PDF 1.3MB)

Rabin, Y., Julian, T.B., Olson, P., Taylor, M.J., Wolmark, N. (1998): Evaluation of post cryosurgery injury in a sheep breast model using the vital stain 2,3,5-triphenyltetrazolium chloride. CryoLetters, 19(4):255-262. Article (PDF 2.6MB)

Rabin, Y., Julian, T.B., Olson, P., Taylor, M.J., Wolmark, N. (1999): Long-term follow-up post-cryosurgery in a sheep breast model. Cryobiology, 39:29-46. Article (PDF 0.6MB)

Rabin, Y., Julian, T.B., Olson, P., Taylor, M.J., Wolmark, N. (1999): Cryosurgery for breast malignancies: apparatus and techniques. In: Advances in Heat and Mass Transfer in Biotechnology. ASME IMECE 1999, Nashville, Tennessee. HTD-Vol. 363, BED-Vol. 44, pp. 65-70 Article (PDF 1.6MB)

Rabin, Y., Julian, T.B., Wolmark, N. (1999): Method and apparatus for heating during cryosurgery. US Patent No. 5,899,897 Patent (PDF 1.4MB)

Rabin, Y., Julian, T.B., Wolmark, N. (2000): Method and apparatus for minimal-invasive cryosurgery. US Patent No. 6,039,730 Patent (PDF 1.6MB)

Rabin, Y. (2001): Imaging of breast cryosurgery. In: Atlas of Cryosurgery (Korpan, N.K., Ed.), Springer-Verlag, Vienna, Austria, pp. 344-353. Article (PDF 4.7MB)

Rabin, Y., Julian, T.B., Olson, P. (2001): Minimally invasive breast cryosurgery. In: Basics of Cryosurgery (Korpan, N.K., Ed.), Springer-Verlag, Vienna, Austria, pp. 213-223. Web Page

Rabin, Y., Julian, T.B., Wolmark, N. (2004): Method and apparatus for cryosurgery. US Patent No. 6,786,902 B1 Patent (PDF 1.2MB)

Computerized Planning of Cryosurgery

Rabin, Y., Stahovich, T.F. (2003): Cryoheater as a means of cryosurgery control. Physics in Medicine and Biology, 48:619-632. Article (PDF 0.4MB)

Lung, D.C., Stahovich, T.F., Rabin, Y. (2004): Computerized planning for multiprobe cryosurgery using a force-field analogy. Computer Methods in Biomechanics and Biomedical Engineering, 7(2):101-110. Article (PDF 0.3MB)

Rabin, Y., Lung, D.C., Stahovich, T.F. (2004): Computerized planning of cryosurgery using cryoprobes and cryoheaters. Technology in Cancer Research & Treatment, 3(3):229-243. Article (PDF 1.1MB)

Mathematical Modeling of Phase Change Problems

Rabin, Y., Korin, E. (1993): An efficient numerical solution for the multidimensional solidification (or melting) problem using a microcomputer. International Journal of Heat and Mass Transfer, 36(3):673‑683. Article (PDF 1.1MB)

Rabin, Y. (1995): Approximate solution of the inverse-Stephan problem in Cartesian, cylindrical and spherical geometries. In: Inverse Problems in Bioheat and Mass Transfer. IMECE 1995, San-Francisco, California. HTD-Vol. 322/BED-Vol. 32, pp. 1-4. Article (PDF 0.5MB)

Rabin, Y., Shitzer, A. (1995): Exact solution to the one‑dimensional inverse Stefan problem in non‑ideal biological tissues. ASME Journal of Heat Transfer, 117(2):425-431. Article (PDF 1.2MB)

Rabin, Y., Shitzer, A. (1997): Combined solution to the inverse Stefan problem for successive freezing/thawing in non‑ideal biological tissues. ASME Journal of Biomechanical Engineering, 119(2):146-152. Article (PDF 1.4MB)

Rabin, Y., Shitzer, A. (1998): Numerical solution of the multidimensional freezing problem during cryosurgery. ASME Journal of Biomechanical Engineering, 120(1):32-37. Article (PDF 1.4MB)

Rabin, Y., Maytal, B-Z. (1999): Thermal analysis of cryocycling. CryoLetters, 20(2):95-102. Article (PDF 0.5MB)

Rabin, Y. (2000): The effect of temperature-dependent thermophysical properties in heat transfer simulations of biomaterials in cryogenic temperatures. CryoLetters, 21:163-170. Article (PDF 0.8MB)

Rabin, Y., Stahovich, T.F. (2002): The thermal effect of urethral warming during cryosurgery. CryoLetters, 23:361-374. Article (PDF 0.2MB)

Rossi, M.R., Rabin, Y. (2007): Analysis of a numerical scheme for bioheat simulations of cryosurgery and its experimental validation on a phantom material. MSV'07- The 2007 International Conference on Modeling, Simulation and Visualization Methods, Las Vegas, Nevada, USA (June 25-28) Article (PDF 0.2MB)

Solid Mechanics Aspects of Low-Temperature Biology

Rabin, Y., Steif, P.S. (1996): Analysis of thermal stresses around a cryosurgical probe. Cryobiology, 33:276-290. Article (PDF 0.3MB)

Rabin, Y., Steif, P.S. (1998): Thermal stresses in a freezing sphere and its application to cryobiology. ASME Journal of Applied Mechanics, 65(2):328-333. Article (PDF 0.9MB)

Rabin, Y., Steif, P.S. (1999): Thermal stress modeling of freezing biological tissues. In: Advances in Heat and Mass Transfer in Biotechnology. IMECE 1999, Nashville, Tennessee. HTD-Vol. 363, BED-Vol. 44, pp. 183-188. Article (PDF 0.2MB)

Dennis, B.H., Dulikravich, G.S., Rabin, Y. (2000): Optimization of organ freezing protocols with specified allowable thermal stress levels. IMECE 2000, Orlando, FL, November 5-10, HTD-Vol. 368/BED-Vol. 47, pp. 33-48. Article (PDF 0.2MB)

Rabin, Y., Steif, P.S. (2000): Thermal stress modeling in cryosurgery. International Journal of Solids and Structures 37:2363-2375. Article (PDF 0.3MB)

Rabin, Y., Steif, P.S. (2005): Letter-to-the-Editor: Analysis of thermo-mechanical stress in cryopreservation, CryoLetters, 26(6):409-411 Article (PDF 0.1MB)

Steif, P.S., Palastro, M.C, Rabin, Y. (2007): Analysis of the effect of partial vitrification on stress development in cryopreserved blood vessels. Medical Engineering & Physics, 29:661-670 Article (PDF 0.5MB)

Rabin, Y., Steif, P.S (2006): Solid mechanics aspect of cryobiology. In: Advances in Biopresevation (Baust, J.G., and Baust J.M., Eds.), CRC Taylor & Francis, Chap. 13, pp. 359-382.

Steif, P.S., Palastro, M.C, Rabin, Y. (2007): Continuum mechanics analysis of fracture progression in the vitrified cryoprotective agent DP6. ASME Biomechanical Engineering, 130(2):021006 PubMed

Steif, P.S., Palastro, M.C, Rabin, Y. (2007): The effect of temperature gradients on stress development during cryopreservation via vitrification. Cell Preservation Technology, 5(2):104-115 Article (PDF 0.2MB)

Experimental Solid Mechanics in Cryobiology

Rabin, Y., Steif, P.S., Taylor, M.J., Julian, T.B., Wolmark, N. (1996): An experimental study of the mechanical response of frozen biological tissues at cryogenic temperatures. Cryobiology, 33:472-482. Article (PDF 0.1MB)

Rabin, Y., Olson, P., Taylor, M.J., Steif, P.S., Julian, T.B., Wolmark, N. (1997): Gross damage accumulation in frozen rabbit liver due to mechanical stress at cryogenic temperatures. Cryobiology, 34:394-405. Article (PDF 1.9MB)

Rabin, Y., Taylor, M.J., Wolmark, N. (1998): Thermal expansion measurements of frozen biological tissues at cryogenic temperatures. ASME Journal of Biomechanical Engineering, 120(2):259-266. Article (PDF 1.6MB)

Rabin, Y., Bell, E. (2003): Thermal expansion measurements of cryoprotective agents. Part I: A new experimental apparatus. Cryobiology, 46:254-263. Article (PDF 1.4MB)

Rabin, Y., Bell, E. (2003): Thermal expansion measurements of cryoprotective agents. Part II: Measurements of DP6 and VS55, and comparison with DMSO. Cryobiology, 46:264-270. Article (PDF 0.9MB)

Plitz, J., Rabin, Y., Walsh, J. (2004): The effect of thermal expansion of ingredients on the cocktails VS55 and DP6. Cell Preservation Technology, 2(3):215-226. Article (PDF 1.9MB)

Rabin, Y., Plitz, J., (2005): Thermal expansion of blood vessels and muscle specimens permeated with DMSO, DP6, and VS55 in cryogenic temperatures. Annals of Biomedical Engineering, 33(9):1213-1228 Article (PDF 0.9MB)

Jimenez Rios, J.L., Rabin, Y. (2006): Thermal expansion of blood vessels in low cryogenic temperatures. Part I: A new experimental device, Cryobiology, 52(2):269-283 Article (PDF 0.5MB)

Jimenez Rios, J.L., Rabin, Y. (2006): Thermal expansion of blood vessels in low cryogenic temperatures. Part II: Measurements of blood vessels vitrified with VS55, DP6, and 7.05M DMSO, Cryobiology, 52(2):284-294 Article (PDF 0.2MB)

Jimenez-Rios, J.L., Steif, P.S., Rabin, Y. (2006): Experimental study of viscoelasticity effects in cryopreservation of blood vessels by means of vitrification. 5^th World Congress on Biomechanics, Munich, Germany

Jimenez Rios, J.L., Rabin, Y. (2007): A New device for mechanical testing of blood vessels at cryogenic temperatures. Journal of Experimental Mechanics 47:337–346 (A special issue on  Mechanics of Organic, Implant, and Bioinspired Materials) Article (PDF 0.7MB)

Jimenez Rios, J.L., Steif, P.S., Rabin, Y., (2007): Stress-strain measurements and viscoelastic response of blood vessels cryopreserved by vitrification. Annals of Biomedical Engineering 35(12):2077-2086 online

Noday*, D.A., Steif, P.S., Rabin, Y. (2009): Viscosity of cryoprotective agents near glass transition: a new device, technique, and data on DMSO, DP6, and VS55. Journal of Experimental Mechanics, in press

See also Temperature-Controlled Microscopy and Macroscopy

Uncertainty in Measurements and Mathematical Modeling

Rabin, Y. (1998): Uncertainty in temperature measurements during cryosurgery. CryoLetters, 19(4):213-224. Article (PDF 1.1MB)

Rabin, Y. (1998): Uncertainty in measurements of fluid temperature in tubes. CryoLetters, 19(5):319-326. Article (PDF 0.1MB)

Rabin, Y. (2003):  A general model for the propagation of uncertainty in measurements into heat transfer simulations and its application to cryobiology. Cryobiology, 46(2): 109-120. Article (PDF 1.9MB)

Temperature-Controlled Microscopy and Macroscopy

Rabin, Y., Podbilewicz, B. (2000): Temperature-controlled microscopy for imaging of living cells: apparatus, thermal analysis, and temperature dependency of embryonic elongation in Caenorhabditis elegans. Journal of Microscopy, 199(3): 214-223. Article (PDF 1.9MB)

Rabin, Y. (2000): Is it reasonable to assume a uniformly distributed cooling rate along the microslide of a directional solidification stage? Journal of Microscopy, 200(1):42-49. Article (PDF 1MB)

Rabin, Y., Taylor, M.J., Walsh, J.R., Baicu, S., Steif, P.S. (2005): Cryomacroscopy of vitrification, Part I: A prototype and experimental observations on the cocktails VS55 and DP6, Cell Preservation Technology, 3(3):169-183 Article (PDF 1.3MB) In conjunction with the Web Page

Steif, P.S., Palastro, M., Wen, C.R., Baicu, S., Taylor, M.J., Rabin, Y. (2005): Cryomacroscopy of vitrification, Part II: Experimental observations and analysis of fracture formation in vitrified VS55 and DP6, Cell Preservation Technology, 3(3):184-200 Article (PDF 1.6MB) In conjunction with the Web Page

Temperature Measurements

Rabin, Y., Rittel, D. (1999): A model for the time response of solid-embedded thermocouples. Experimental Mechanics, 39(1):132-137. Article (PDF 0.1MB)

Rittel, D., Rabin, Y. (2000): An investigation of the heat generated during cyclic loading of two glassy polymers, Part II: Thermal analysis. Mechanics of Materials, 32(3):149-159. Article (PDF 0.3MB)

Rabin, Y., Rittel, D. (2000): Infrared temperature sensing of mechanically loaded specimens: Thermal analysis. Experimental Mechanics, 40(2):197-202. Article (PDF 0.1MB)

Zhang, S., Yang, Y., Barmak, K., Rabin, Y., Asheghi, M. (2004): MEMS based high sensitivity calorimetry, IMECE 2004, Anaheim, CA, USA, IMECE2004- 62332. Article (PDF 0.3MB)

Zhang, S., Rabin, Y., Yang, Y., Asheghi, M. (2007): Nanoscale calorimetry using a suspended bridge configuration, IEEE Journal of Microelectromechanical Systems. Article (PDF 0.9MB)

Energy Storage Systems

Rabin, Y. (1991): Long‑term energy storage in the ground using heat storage elements containing phase change materials, M.Sc. Thesis, Department of Mechanical Engineering, Ben-Gurion University, Be'er Sheva, Israel.

Rabin, Y., Korin, E., Sher, E. (1991): Simplified model for a helical heat exchanger for long‑term energy storage in soil. In: Design and Operation of Heat Exchangers (Roetzel W., Heggs P. T. and Butterworth D., Eds.), pp. 305‑314, Springer Verlag. Article (PDF 1MB)

Rabin, Y., Bar-Niv, I., Korin, E., Mikic, B. (1995): Integrated solar collector storage system based on a salt‑hydrate phase‑change material. Solar Energy, 55(6):435-444. Article (PDF 1.3MB)

Rabin, Y., Korin, E. (1996): Thermal analysis of a helical heat exchanger for ground thermal energy storage in arid zones. International Journal of Heat and Mass Transfer, 39(5):1051-1065. Article (PDF 0.7MB)

Rabin, Y., Korin, E. (1996): Incorporation of phase-change materials into a ground thermal energy storage system: theoretical study. ASME Journal of Energy Resources Technology, 118(3):237-241. Article (PDF 1MB)

Hyperthermia and Thermal Ablation

Rabin, Y. (2002): Is intracellular hyperthermia superior to extracellular hyperthermia in the thermal sense? International Journal of Hyperthermia, 18(3):194-202. Article (PDF 0.1MB)

Rabin, Y. (2002): Cancer treatment by electromagnetic activated nanoheaters. EurekaAlert!

Jacob, H., Rabin, Y. (2003): Temperature-controlled snare. US Patent No. 6,517,538 B1 Patent (PDF 0.5MB)